Announcement PDF RNS Number : 8171U Shield Therapeutics PLC 27 November 2023 Shield Therapeutics plc ("Shield Therapeutics" or the "Company") PDMR Transaction Notification London, UK, 27 November 2023: Shield Therapeutics plc (LSE:STX), a commercial stage pharmaceutical company with a focus on addressing iron deficiency with its lead product Accrufer®/Feraccru® (ferric maltol), confirms that Mr Hans Peter Hasler, Chairman, acquired 2,000,000 Ordinary Shares in the Company on 21 November 2023 at a price of 6.1p per share. Mr Hasler now holds a beneficial interest in 5,500,000 Ordinary Shares. The notification below, which has been made in accordance with the requirements of the EU Market Abuse Regulation, provides further detail. Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them: 1. a. 2. a. b. 3. a. b. 4. a. b. c. Details of the person discharging managerial responsibilities / person closely associated Name Hans Peter Hasler Reason for the notification Position/status Chairman Initial notification Initial /Amendment Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor Name Shield Therapeutics plc LEI 213800G74QWY15FC3W71 Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted Description of the Ordinary shares of 1.5p each in the capital of the Company Financial instrument, type of instrument Identification code ISIN of Ordinary Shares: GB00BYV81293 Nature of the Acquisition of Ordinary Shares transaction Price(s) and volume(s) Price(s) Volume(s) 6.1p d. e. f. Aggregated information · Aggregated volume · Price Date of the transaction Place of the transaction 2,000,000 £122,000 21 November 2023 AIM 2,000,000 For further information please contact: Shield Therapeutics plc Greg Madison, CEO www.shieldtherapeutics.com +44 (0) 191 511 8500 Nominated Adviser and Joint Broker Peel Hunt LLP James Steel/Patrick Birkholm +44 (0)20 7418 8900 Joint Broker Cavendish Capital Markets Ltd Geoff Nash/ George Dollemore/Nigel Birks +44 (0)20 7220 0563 Financial PR & IR Advisor Walbrook PR Paul McManus/ Alice Woodings +44 (0)20 7933 8780 or shield@walbrookpr.com Investor Contact (US Advisor) LifeSci Advisors, LLC John Mullaly +1 617 429 3548 or jmullaly@lifesciadvisors.com About Iron Deficiency and Accrufer®/Feraccru® Clinically low iron levels (aka iron deficiency, ID) can cause serious health problems for adults of all ages, across multiple therapeutic areas. Together, ID and ID with anemia (IDA) affect about 20 million people in the US and represent a $2.3B market opportunity. As the first and only FDA approved oral iron to treat ID/IDA, Accrufer® has the potential to meet an important unmet medical need for both physicians and patients. Accrufer®/Feraccru® (ferric maltol) is a novel, stable, non-salt-based oral therapy for adults with ID/IDA. Accrufer®/Feraccru® has a novel mechanism of absorption compared to other oral iron therapies and has been shown to be an efficacious and well-tolerated therapy in a range of clinical trials. More information about Accrufer®/Feraccru®, including the product label, can be found at: www.accrufer.com and www.feraccru.com. About Shield Therapeutics plc Shield is a commercial stage specialty pharmaceutical company that delivers Accrufer®/Feraccru® (ferric maltol), an innovative and differentiated pharmaceutical product, to address a significant unmet need for patients suffering from iron deficiency, with or without anemia. The Company launched Accrufer® in the U.S. with an exclusive, multi-year collaboration agreement with Viatris. Outside of the U.S., the Company licensed the rights to four specialty pharmaceutical companies. Feraccru® is commercialized in the UK and European Union by Norgine B.V. (Norgine), which also has marketing rights in Australia and New Zealand. Shield also has an exclusive license agreement with Beijing Aosaikang Pharmaceutical Co., Ltd., for the development and commercialization of Accrufer®/ Feraccru® in China, Hong Kong, Macau and Taiwan, with Korea Pharma Co., Ltd. for the Republic of Korea (Korea Pharma), and with KYE Pharmaceuticals Inc. for Canada. Accrufer®/Feraccru® has patent coverage until the mid-2030s. Accrufer®/Feraccru® are registered trademarks of Shield Therapeutics. This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com. RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy. END DSHPPGPPGUPWGMM