Announcement PDF RNS Number : 1395M Shield Therapeutics PLC 09 January 2023 TR-1: Standard form for notification of major holdings 1. Issuer Details ISIN GB00BYV81293 Issuer Name SHIELD THERAPEUTICS PLC UK or Non-UK Issuer UK 2. Reason for Notification An acquisition or disposal of voting rights; An event changing the breakdown of voting rights 3. Details of person subject to the notification obligation Name Jupiter Fund Management PLC City of registered office (if applicable) London Country of registered office (if applicable) United Kingdom 4. Details of the shareholder Name City of registered office Country of registered office Northern Trust 5. Date on which the threshold was crossed or reached 06-Jan-2023 6. Date on which Issuer notified 09-Jan-2023 7. Total positions of person(s) subject to the notification obligation Resulting situation on the date on which % of voting rights attached to shares (total of 8.A) % of voting rights through financial instruments (total of 8.B 1 + 8.B 2) Total of both in % (8.A + 8.B) Total number of voting rights held in issuer 6.700000 0.000000 6.700000 37146992 threshold was crossed or reached Position of previous notification (if applicable) 4.680000 0.000000 4.680000 8. Notified details of the resulting situation on the date on which the threshold was crossed or reached 8A. Voting rights attached to shares Number of direct Class/Type of shares voting rights ISIN code(if possible) (DTR5.1) Number of indirect % of direct voting % of indirect voting voting rights (DTR5.2.1) rights (DTR5.1) rights (DTR5.2.1) 37146992 GB00BYV81293 6.700000 37146992 Sub Total 8.A 6.700000% 8B1. Financial Instruments according to (DTR5.3.1R.(1) (a)) Type of financial instrument Number of voting rights that may be Expiration Exercise/conversion acquired if the instrument is date period exercised/converted % of voting rights Sub Total 8.B1 8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b)) Type of financial instrument Expiration date Exercise/conversion Physical or cash period settlement Number of voting rights % of voting rights Sub Total 8.B2 9. Information in relation to the person subject to the notification obligation 2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary) Ultimate controlling Name of controlled person undertaking Jupiter Fund Management Plc ( Chain 1) Jupiter Fund Management Plc ( Chain 1) Jupiter Fund Management Plc ( Chain 1) Jupiter Fund Management Group Limited Jupiter Asset Management % of voting rights % of voting rights if it equals or is through financial higher than the instruments if it equals notifiable or is higher than the threshold notifiable threshold Total of both if it equals or is higher than the notifiable threshold 0.000000 0.000000 0.000000% 0.000000 0.000000 0.000000% 0.000000 0.000000 0.000000% Group Limited Jupiter Fund Management Plc ( Chain 1) Knightsbridge Asset Management Limited 0.000000 0.000000 0.000000% Jupiter Fund Management Plc ( Chain 1) Jupiter Investment Management Group Limited 0.000000 0.000000 0.000000% Jupiter Fund Management Plc ( Chain 1) Jupiter Asset Management Limited 6.700000 0.000000 6.700000% Jupiter Fund Management Plc (Chain 2) Merian Global Investors Limited 0.000000 0.000000 0.000000% Jupiter Fund Management Plc (Chain 2) Merian Global Investors (Jersey) Limited 0.000000 0.000000 0.000000% Jupiter Fund Management Plc (Chain 2) Merian Global Investors (Finance) Limited 0.000000 0.000000 0.000000% Jupiter Fund Management Plc (Chain 2) Merian Global Investors Holdings Limited 0.000000 0.000000 0.000000% Jupiter Fund Management Plc (Chain 2) Jupiter Investment Management Limited 0.000000 0.000000 0.000000% 10. In case of proxy voting Name of the proxy holder The number and % of voting rights held The date until which the voting rights will be held 11. Additional Information 12. Date of Completion 09.01.2023 13. Place Of Completion London, UK This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com. RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy. END HOLBLMATMTTMBMJ